(03-10-2018, 08:22 AM)Richardg8092 Wrote: Both references point to one single paper published in 2009 which can be read in full here.
For mine, this paper is all over the place.
For instance, they site the case of clonazepam-induced liver injury (Am J Gastroenterol. 1988 May;83(5):576-7.)
But when you read that paper you find "It is suggested that the damage was of the metabolic idiosyncrasy type".
Back at our 2009 article and they say "idiosyncratic drug reactions do not occur in most patients at any dose"
So what are we left to conclude?
I'd say it would be something like "Clonazepam-induced liver injury does not occur in most patients at any dose".
Well, that's reassuring.
The 2009 paper also sites a mysterious paper "Chronic administration of antidepressant drugs including nitrazepam was reported to induce severe hepatic disorders" (Seki et al., 2008) But when you click on the link there's no mention of nitrazepam. Hmmmm.....
As far as I know, Nitrazepam isn't considered to be a member of any class of antidepressant drugs. They're just not "Same Same".
And to conclude my rant, comparing what happens inside a human to what happens in a cell culture incubated at 37°C in for 24hrs an atmosphere of 5% CO2 and 95% air is just plain crazy.
In their Discussion, the authors of the 2009 paper note"....it is very difficult to extrapolate from an in vitro study to in vivo in humans....."
Oh God, never a truer word were spoken!
I think we can relax. In the real world, (virtually) no-one's liver or kidney is going to collapse from a few doses of nitrazepam or clonazepam.
If u dont mind sharing what did it say about antidepressants and liver damage. Thanks