It belongs to a class of drugs called Dual Orexin Receptor Antagonists (DORA). Drugs in this class include:
$uv0rexant (Bel$0mra) half-life 12 hours
L3mb0rexant (D@yvig0) half-life 17–55 hours
D@rid0rex@nt (Quv|v|q) half-life 8 hours
I would think that a half-life of 17-55 hours is going to produce a lot of next-day drowsiness but, OTOH, it might be what's needed to keep some people asleep for more than a few hours at a time. Eight hours half-life probably is not going to keep an insomniac asleep for the full eight hours but, OTOH, would be the best choice if next day drowsiness is absolutely not an option (heavy equipment operator, for example). Twelve hour half-life probably the best choice for most insomniacs.
I became interested in this class of drugs when I was fasting to lose weight (taking Mounj@ro by Rx). Some people report that these GLP-1 weight loss meds give them insomnia. I was having a hard time sleeping through the night even though I didn't have any trouble falling asleep. I had never had any trouble with sleep in the past, except intermittently when under acute stressful life situations. Researching this, I discovered that there is a phenomenon that one might term "Early Awakening due to Starvation Response." As it turns out, ketogenic dieters and intermittent fasters can also suffer from the same problem. The problem then, is not produced directly by the GLP-1, but is caused by the body’s response to prolonged caloric deficit. Summary of the process outlined here:
https://peterattiamd.com/how-fasting-can-impact-sleep/
TL;DR: Your caveman brain produces a hormone called OREXIN to get you up and moving to search for food before you starve to death.
There are many, many different types of problems with sleeping with many, many different causes and many, many different solutions. The class of drugs discussed here, Dual Orexin Receptor Antagonists, are the perfect solution if this is the cause of your insomnia.
$uv0rexant (Bel$0mra) half-life 12 hours
L3mb0rexant (D@yvig0) half-life 17–55 hours
D@rid0rex@nt (Quv|v|q) half-life 8 hours
I would think that a half-life of 17-55 hours is going to produce a lot of next-day drowsiness but, OTOH, it might be what's needed to keep some people asleep for more than a few hours at a time. Eight hours half-life probably is not going to keep an insomniac asleep for the full eight hours but, OTOH, would be the best choice if next day drowsiness is absolutely not an option (heavy equipment operator, for example). Twelve hour half-life probably the best choice for most insomniacs.
I became interested in this class of drugs when I was fasting to lose weight (taking Mounj@ro by Rx). Some people report that these GLP-1 weight loss meds give them insomnia. I was having a hard time sleeping through the night even though I didn't have any trouble falling asleep. I had never had any trouble with sleep in the past, except intermittently when under acute stressful life situations. Researching this, I discovered that there is a phenomenon that one might term "Early Awakening due to Starvation Response." As it turns out, ketogenic dieters and intermittent fasters can also suffer from the same problem. The problem then, is not produced directly by the GLP-1, but is caused by the body’s response to prolonged caloric deficit. Summary of the process outlined here:
https://peterattiamd.com/how-fasting-can-impact-sleep/
TL;DR: Your caveman brain produces a hormone called OREXIN to get you up and moving to search for food before you starve to death.
There are many, many different types of problems with sleeping with many, many different causes and many, many different solutions. The class of drugs discussed here, Dual Orexin Receptor Antagonists, are the perfect solution if this is the cause of your insomnia.