11-10-2017, 10:04 PM
Yes I did get noticeable anxiolytic effects from GABA at 10g, not something I would recommend for day to day use but it is useful if you are in a pinch. Probably the same anti anxiety effects as 10-30mg diazepam (depending on tolerance) but lasting much longer. Perhaps there are GABA receptors in the gut- akin to loperamide which is actually a very strong opiate (a bit less potent than fentanyl) but the molecule is too big to pass the BBB. There are however opiate receptors in the gut which is why it is marketed as an effective treatment for diarrhea. Maybe GABA is also absorbed in the gut?
Thanks for answering my questions about gabapentanoid addiction. The type of anxiety I suffer from does not require consistent daily use so I think occasional use of pregabalin should probably be ok. I find the GPs in this country always seem to want to prescribe antidepressants before anything else, I know they can help many people but since I only take anxiolytics occasionally when required, which is less and less these days (touch wood), I shall discuss the options of gabapentoids with my GP. Another problem in the UK I find is that even if you show some knowledge of potential medicine it can be marked as drug seeking behaviour. I can understand it in the case of some medicines but they should give us credit for doing a bit of research ourselves, before taking any medicine I make sure to familiarise myself with all effects, interactions etc. Unfortunately many people don't pay much mind what they put in their bodies.
Barq- I am sure in 10 years there will be another set of medicines to replace the gabapentoids but I too hope that the dangers are more well publicised. Alas the pharmacutical companies will always play down the dangers- just the like the famous oxycontin which was originally marketed as an addiction free solution for morphine. I think better public understanding is key, most people trust their doctors complicity which is to be expected but informing the public about the dangers and benefits of all drugs would do the public health service a great benefit.
Thanks for answering my questions about gabapentanoid addiction. The type of anxiety I suffer from does not require consistent daily use so I think occasional use of pregabalin should probably be ok. I find the GPs in this country always seem to want to prescribe antidepressants before anything else, I know they can help many people but since I only take anxiolytics occasionally when required, which is less and less these days (touch wood), I shall discuss the options of gabapentoids with my GP. Another problem in the UK I find is that even if you show some knowledge of potential medicine it can be marked as drug seeking behaviour. I can understand it in the case of some medicines but they should give us credit for doing a bit of research ourselves, before taking any medicine I make sure to familiarise myself with all effects, interactions etc. Unfortunately many people don't pay much mind what they put in their bodies.
Barq- I am sure in 10 years there will be another set of medicines to replace the gabapentoids but I too hope that the dangers are more well publicised. Alas the pharmacutical companies will always play down the dangers- just the like the famous oxycontin which was originally marketed as an addiction free solution for morphine. I think better public understanding is key, most people trust their doctors complicity which is to be expected but informing the public about the dangers and benefits of all drugs would do the public health service a great benefit.