03-06-2018, 05:27 AM
This post does not affect me personally but still thought it would be a valid subject for those who it may affect.
Many of the drugs of the benzodiazepine class suffer biotransformation in the liver and are eliminated by renal excretion, therefore, in patients with any hepatic or renal impairment the dose of such drugs should be prescribed with caution and without exaggeration, to prevent that in cases of renal failure the action of these drugs could be prolonged (increase in half-life) and cause undesirable side effects such as, for example, the use of midazolam in chronic renal failure patients postoperatively which can result in continued sedation.
Renal failure is a condition in which the kidneys lose their ability to perform their basic functions (eliminate toxic substances to the body, keep regulated the hidroelectrolyte balance of the body, regulate basic-acid balance, hormone production, excrete urine and exogenous substances such as drugs), such deficiency can be acute when loss occurs in sudden and rapid way or chronic when this loss is slow, progressive and irreversible. The latter is classified in stages, according to its evolution: 0 (risk of kidney disease by having high blood pressure or diabetes), 1 (kidney damage), 2 (kidney damage and mild glomerular filtration), 3 (moderate glomerular filtration) 4 (advanced glomerular filtration) and 5 (renal failure, requiring dialysis or transplantation).
Xfizzler
Many of the drugs of the benzodiazepine class suffer biotransformation in the liver and are eliminated by renal excretion, therefore, in patients with any hepatic or renal impairment the dose of such drugs should be prescribed with caution and without exaggeration, to prevent that in cases of renal failure the action of these drugs could be prolonged (increase in half-life) and cause undesirable side effects such as, for example, the use of midazolam in chronic renal failure patients postoperatively which can result in continued sedation.
Renal failure is a condition in which the kidneys lose their ability to perform their basic functions (eliminate toxic substances to the body, keep regulated the hidroelectrolyte balance of the body, regulate basic-acid balance, hormone production, excrete urine and exogenous substances such as drugs), such deficiency can be acute when loss occurs in sudden and rapid way or chronic when this loss is slow, progressive and irreversible. The latter is classified in stages, according to its evolution: 0 (risk of kidney disease by having high blood pressure or diabetes), 1 (kidney damage), 2 (kidney damage and mild glomerular filtration), 3 (moderate glomerular filtration) 4 (advanced glomerular filtration) and 5 (renal failure, requiring dialysis or transplantation).
Xfizzler
There is more time than life .... so make it count!