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10-16-2016, 10:02 PM
(This post was last modified: 10-16-2016, 10:04 PM by Colton4Trmz.)
"The results of the current study suggest that tr@madol-acetaminophen in tablet form may represent an attractive alternative treatment option for chronic lower back pain patients with  depression or apathy"
The full study can be found online here:
https://www.hindawi.com/journals/prm/2016/7458534/abs/
Well now, it's clear to see where my bias is here. Tr@madol helped me with my back pains and maintained my anxiety & depression, all with a single pill. Now, after 5 years of successful monitoring of my pain and mental states, it has become impossible for me at this point to get any more of the one thing that has been able to give me peace every day. Thank you govt for cracking down on doctors, leaving me out to dry and agitate through the healthcare system.
the nerve of the govt to tell me what should work for me. The reality is that i was perfectly fine. Now i'm not. 
Hopefully more studies will show the benefits of tr@madol.
It needs to become otc in the United States 
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What blows my mind is this use to be OTC. Hell, when I'd go to my doctor back around 2010, he'd give me a boxes just to clear room. I never used them and threw them away. Hopefully things will work out for you.
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I am happy hearing all the support. This forum is my new favorite thing.
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Hi Colton,
I have a similar experience to you. Tramadol for pain, but then found it brightened my mood. Been able to hold down a very stressful and demanding job, in part thanks to tramadol. I have a prescription, but it isn't enough so have to top up from elsewhere. Anyway, interesting article you found there (and so nice when you can read a whole journal article, rather than just the abstract and then hitting the paywall).
Venlafaxine is antidepressant (SNRI) that has many similarities with tramadol. Can you get that prescribed for the depression/anxiety, even if it doesn't do anything for pain?
In the interests of safety, I should point out that tramadol can cause seizures especially at higher doses, among those with a low seizure threshold, or in combination with certain other medications. Be safe.
Best wishes,
barq
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This is very interesting, I haven't ever heard of a link between tramadol and depression. I take tramadol for chronic pain and have also been on Zoloft for over ten years for depression/anxiety. Thinking back, my depression has been very well controlled over the past five years or so since I started taking the tramadol. Hmm
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To be honest I feel like most opi@tes and Tr@m is a synthetic opi@te can help with depression. They just make you feel happy. They make you want to talk to people and interact. Although going off these can be scary, why should we go off something that makes us "better". Of course there are people that can function day to day without these bit other people are wired differently and need help. It would be nice if we could just make things available and let people make their own choices.
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11-08-2016, 10:59 PM
(This post was last modified: 11-08-2016, 11:18 PM by nickolyko.)
(10-16-2016, 10:02 PM)Colton4Trmz Wrote: "The results of the current study suggest that tr@madol-acetaminophen in tablet form may represent an attractive alternative treatment option for chronic lower back pain patients with depression or apathy"
The full study can be found online here:
https://www.hindawi.com/journals/prm/2016/7458534/abs/
Well now, it's clear to see where my bias is here. Tr@madol helped me with my back pains and maintained my anxiety & depression, all with a single pill. Now, after 5 years of successful monitoring of my pain and mental states, it has become impossible for me at this point to get any more of the one thing that has been able to give me peace every day. Thank you govt for cracking down on doctors, leaving me out to dry and agitate through the healthcare system.
the nerve of the govt to tell me what should work for me. The reality is that i was perfectly fine. Now i'm not.
Hopefully more studies will show the benefits of tr@madol.
It needs to become otc in the United States
Tramadol acts as a μ-opioid receptor agonist,[serotonin reuptake inhibitor and releasing agent,[49 Wrote: norepinephrine reuptake inhibitor,NMDA receptor antagonist -HT2C receptor antagonist nicotinic acetylcholine receptor antagonist,TRPV1 receptor agonist M1 and M3 muscarinic acetylcholine receptor antagonist.Tramadol was the ultimate pain medicine when it was mass introduced. It has so many actions that still we do not know all of them. It is a week serotonin enhancer since it is blocking the reaptake via inhibition. So it is a painkiller and fights depression. So it is a double hight especially over 200 mg and its action has np plateau effect like cod.The problem is it can cause seizures and unfortunately it does so when combined with benzos other opoioids and alcohol . Tolerant guys can easy overcome 800 mg but then the seizure risk is very high. Some friends of mine experienced bad seizures from tram. But its a nice pain killer and its not so dangerous as the real op stuff as H or Oc. pid='53039' dateline='1476655355']"The results of the current study suggest that tr@madol-acetaminophen in tablet form may represent an attractive alternative treatment option for chronic lower back pain patients with depression or apathy"
The full study can be found online here:
https://www.hindawi.com/journals/prm/2016/7458534/abs/
Well now, it's clear to see where my bias is here. Tr@madol helped me with my back pains and maintained my anxiety & depression, all with a single pill. Now, after 5 years of successful monitoring of my pain and mental states, it has become impossible for me at this point to get any more of the one thing that has been able to give me peace every day. Thank you govt for cracking down on doctors, leaving me out to dry and agitate through the healthcare system.
the nerve of the govt to tell me what should work for me. The reality is that i was perfectly fine. Now i'm not.
Hopefully more studies will show the benefits of tr@madol.
It needs to become otc in the United States
The truth will set you free .
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Personally, I wish it was OTC; however, I did know a frog that accidentally had seizure from tram. I think it may be because of that risk that it is not OTC. Not sure.
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Definitely. My doctor warned me of the potential for seizures. Need to make sure you take under a certain amount in a 24 hour period. But this pain medication really helped me with my back. But losing health insurance has definitely not helped with my back.
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11-11-2016, 06:44 AM
(This post was last modified: 11-11-2016, 06:45 AM by CryptsOfEternity.)
Seeing as it is practically, 99% the same molecule as Effexor (valenfaxine), which does not have mu opioid receptor activity while its extremely close chemical brother is indeed Tramadol. Now as for how good that Tramadol is also an SNRI....that's a very different thing.
I noticed in the forum I have mods on, that's similar to this, but different in major ways (can't talk about sources at all), that since it was unleashed, the US, UK, Aussies, South Africans all tell me that Tramadol is very much used there.
Here in Canada...no, either there was too many bad reactions with people already on antidepressants that Health Canada took notice of the doctors not understanding what was going on...I don't know outside the US and Canada, but GP's or ER doctors are not very good in Pharmacology, they have to take 2-3 classes for that and that's all, I out-logic some doctors at the ER sometimes and boy do they hate it at the moment, but then respect you more and ask you what have you studied and what university. Hah.
But yes, Tramadol, well it's, no pure Tramadol IR pills. Tramacet is very rarely scripted here, they'll go with Empracets or pure codeine pills if you take tylenol a lot already. Once I got a script for it and I felt the "lowering of seizure threshold", was out of benzos, felt really strange, walked to the ER in a snowstorm which is 25 minutes away from where I lived (near campus) to tell the poor ER doc who had nothing to do with this how pissed off I was that the woman who was working his shift before him (who gave me what I asked for, I wanted to try it as I "heard it was a new less addictive painkiller)...that was circa 2007, it was newish in Canada, I know it was in the US back in 2000 or even before. Mostly as just Ultram and Ultracet as you call it. We got Tramacet and they just approved, after about 3-4 attempts to have the US XR version of tramadol accepted here, another company had to invent a whole new pill and it's Zytram XL...never saw or taken it, but you'd have to hold a gun to my head for me to take a Zytram XL, especially a long duration one. I would be seizing away for sure, like how Effexor made me feel so strange, at the starting dose of Effexor XR 37.5mg, extreme nausea, pupils like if I did LSD/mushrooms.
So here we decided to stick with good old codeine for a basic more-than-an-nsaid, we're the only country with CodeineContins too.
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