06-27-2017, 08:50 PM
It is true that each medicine action depends in the person though. And Oxy and Tapentadol have a common action both is act as agonist of the μ-opioid receptor and recent data point that both release more endorfins from CNS altering pain perception. But Oxy is much more euphoric than Tapentadol. Especialy Oxy in the IR form can make the big difference not even morphine can give such a high as immediate Oxy can give . Tapentadol needs a lot of attention if you drink as well . Combination with alchool is very dangerous . Combination with SSRIs-SNRIs, SRAs, serotonin receptor agonists and/or MAOIs can lead to serotonin syndrome and with MAOIs may also result in an adrenergic storm. Use of tapentadol with alcohol produce more respiratory depression than each amount of drug or alcoholby itself can produce .Some say it is multiple and some took the trip of no return by this combination .I also had the passing experience with just 2 glass of wine and 100 mg. Tapentadol is partially metabolized by the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 )
Tapentadol should be used with great caution in those who are taking one or more anticholinergic drugs, as this combination may result in urine retention which can result in serious renal damage and is considered a medical emergency.
Also I do not recomend use with Tramadol as some believe that tapentadol augments action of Tramadol. I say yes but seizures will come or a very unpleasnt tremor and agitation killing any pleasure .
Tapentadol should be used with great caution in those who are taking one or more anticholinergic drugs, as this combination may result in urine retention which can result in serious renal damage and is considered a medical emergency.
Also I do not recomend use with Tramadol as some believe that tapentadol augments action of Tramadol. I say yes but seizures will come or a very unpleasnt tremor and agitation killing any pleasure .